Work

Deterministic regularization of three-dimensional optical diffraction tomography

Year: 2011

Type: article

Abstract: In this paper, we discuss a deterministic regularization algorithm to handle the missing cone problem of three-dimensional optical diffraction tomography (ODT). The missing cone problem arises in most practical applications of ODT and is responsible for elongation of the reconstructed shape and underestimation of the value of the refractive index. By applying positivity and piecewise-smoothness constraints in an iterative reconstruction framework, we effectively suppress the missing cone artifact and recover sharp edges rounded out by the missing cone, and we significantly improve the accuracy of the predictions of the refractive index. We also show the noise-handling capability of our algorithm in the reconstruction process.

Source: Journal of the Optical Society of America A

DOI: 10.1364/josaa.28.001554

Authors: Yongjin Sung, Ramachandra R. Dasari

Institution: Massachusetts Institute of Technology

Language: English

Topic: Digital Holography and Microscopy

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, Kwanjeong Educational Foundation, National Institutes of Health, National Center for Research Resources

Awards: G1984002912, IDBR: Field-Based Tomographic Microscopy Instruments, G4823887657, G9000192120