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Sulphadiazine-induced renal stones in a 63-year-old HIV-infected man treated for toxoplasmosis

Year: 2012

Type: article

Abstract: A 63-year-old man was admitted for investigation of blurred vision and multiple ring-enhancing lesions on cranial MRI. Histopathological examination of tissue obtained at brain biopsy showed multiple Toxoplasma gondii cysts. He was started on a combination of sulphadiazine and pyrimethamine for cerebral toxoplasmosis and was subsequently diagnosed with HIV-1 infection. He then developed acute renal failure and flank pain and was diagnosed with bilateral vesico-uretric calculi requiring bilateral stent insertion. The retrieved renal calculi were negative for the common stones that are routinely tested for in our laboratory and had the macroscopic characteristics of a sulphadiazine stone. His renal failure responded to cessation of the sulphadiazine.

Source: BMJ Case Reports

DOI: 10.1136/bcr-2012-006638

Authors: Benjamin David McGettigan, Meilyn Hew, Elizabeth Phillips, Andrew McLean-Tooke

Institutions: Royal Perth Hospital, Fremantle Hospital, Sir Charles Gairdner Hospital

Language: English

Topic: Kidney Stones and Urolithiasis Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2102680822

FWCI: 0.515

Cites: 10

Cited by: 11

Related to: 10