Year: 2004
Type: article
Abstract: The post-weaning period in pigs is characterized by an immediate but transient drop in feed intake resulting in severe undernutrition and growth check.This in turn affects various aspects of small intestinal architecture and function leading to gut-associated disorders and often diarrhea.Among these, villus atrophy and digestive enzyme activity depression have been documented.More recent investigations clearly demonstrate early signs of local inflammation including immune cell infiltration and increased pro-inflammatory cytokine gene expression, signs of cytoprotection through up-regulation of so-called heat shock proteins, indications of tissue alterations by proteases (stromelysin) and finally epithelial functional disorders in mineral absorption/secretion and permeability.This is followed by a regenerative phase, probably stimulated by feed intake resumption, resulting in down-regulation of many intestinal indicators.However, some of them then display new spatio-temporal adult-type adaptive patterns of maturation.A limited number of substances, particularly nitrogenous compounds and complex preparations of animal origin (colostrum, plasma) have proven to be successful, at least partly, in minimizing post-weaning intestinal disturbances.Thus further research in intestinal physiology, in association with microbiology and immunology, is warranted to strengthen our understanding of the mechanisms of gut disorders in order to provide a better rational basis for designing suitable alternatives to in-feed antibiotics for pigs. intestine / nutrition / pathophysiology / pig / weaningRésumé -Fonctionnement normal et perturbé du tube digestif du jeune porcelet : physiologie.La période post-sevrage est caractérisée, chez le porcelet, par une réduction immédiate mais transitoire de la consommation d'aliment, conduisant à un état de sous-nutrition sévère et d'arrêt de croissance.Ceci affecte divers aspects de l'architecture et des fonctions de l'intestin grêle générant des troubles digestifs, voire des diarrhées.Parmi ceux-ci, l'atrophie villositaire et la dépression des activités enzymatiques digestives ont souvent été rapportées.Des recherches plus récentes ont
Source: Animal Research
Language: English
Subfield: Animal Science and Zoology
Domain: Life Sciences
Open Access status: bronze
Funder: European Commission
OpenAlex ID: W2102742338