Year: 2014
Type: preprint
Abstract: The discovery of tuberculosis (TB) biomarkers is an important goal in current TB research, because the availability of such markers would have significant impact on TB prevention and treatment. Correlates of protection would greatly facilitate vaccine development and evaluation, whereas correlates of TB disease risk would facilitate early diagnosis and help installing early or preventive treatment. Currently, no such markers are available. This review describes several strategies that are currently being pursued to identify TB biomarkers and places these in a clinical context. The approaches discussed include both targeted and untargeted hypothesis-free strategies. Among the first are the measurements of specific biomarkers in antigen-stimulated peripheral blood, in serum or plasma, and detailed immune cell phenotyping. Among the latter are proteomic, genomic, and transcriptomic (mRNA, miRNA) approaches. Recent and promising developments are described.
Institutions: Stellenbosch University, Leiden University Medical Center
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Bill and Melinda Gates Foundation, European Commission, National Research Foundation, South African Medical Research Council, Department of Science and Technology, Ministry of Science and Technology, India, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Medical Research Council, European and Developing Countries Clinical Trials Partnership
Awards: G1036362424, G3623511769
OpenAlex ID: W2102764186