Work

Patterning embryos with oscillations: structure, function and dynamics of the vertebrate segmentation clock

Year: 2012

Type: review

Abstract: The segmentation clock is an oscillating genetic network thought to govern the rhythmic and sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the precursors of the segmented vertebral column. Understanding how the rhythmic signal arises, how it achieves precision and how it patterns the embryo remain challenging issues. Recent work has provided evidence of how the period of the segmentation clock is regulated and how this affects the anatomy of the embryo. The ongoing development of real-time clock reporters and mathematical models promise novel insight into the dynamic behavior of the clock.

Source: Development

DOI: 10.1242/dev.063735

Authors: Andrew C. Oates, Luis G. Morelli, Saúl Ares

Institutions: Max Planck Institute of Molecular Cell Biology and Genetics, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Max Planck Institute for the Physics of Complex Systems

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Max-Planck-Gesellschaft, Ministerio de Ciencia e Innovación

OpenAlex ID: W2102910500

FWCI: 2.595

Cites: 109

Cited by: 398

Related to: 9