Work

Reversal of transforming growth factor-β induced epithelial-to-mesenchymal transition and the ZEB proteins

Year: 2012

Type: article

Abstract: BACKGROUND: The dynamic process of epithelial-to-mesenchymal transition (EMT) is a causal event in kidney fibrosis. This cellular phenotypic transition involves activation of transcriptional responses and remodeling of cellular structures to change cellular function. The molecular mechanisms that directly contribute to the re-establishment of the epithelial phenotype are poorly understood. RESULTS: Here, we discuss recent studies from our group and other laboratories identifying signaling pathways leading to the reversal of EMT in fibrotic models. We also present evidence that transcriptional factors such as the ZEB proteins are important regulators for reversal of EMT. CONCLUSION: These studies provide insights into cellular plasticity and possible targets for therapeutic intervention.

Source: Fibrogenesis & Tissue Repair

DOI: 10.1186/1755-1536-5-s1-s28

Authors: Shreyasi Das, Bryan N Becker, F Michael Hoffmann, Janet E Mertz

Institutions: Sanford Burnham Prebys Medical Discovery Institute, University of Wisconsin–Madison, University of Wisconsin Health, University of Wisconsin System

Language: English

Topic: TGF-β signaling in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Cancer Institute