Work

Adoptive Transfer of Umbilical Cord Blood-Derived Regulatory T Cells and Early Viral Reactivation

Year: 2013

Type: article

Abstract: We previously reported that the infusion of ex vivo expanded umbilical cord blood (UCB)-derived natural regulatory T cells (nTregs) infused immediately after UCB transplantation was associated with a reduced incidence of acute graft-versus-host disease (GVHD) relative to historical control subjects [1]. We did not observe an increased incidence of opportunistic infections or relapse, suggesting the transient nature of nTreg provided sufficient immune suppression to control GVHD without long-term deleterious effects.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2013.06.004

Authors: Claudio G. Brunstein, Bruce R. Blazar, Jeffrey S. Miller, Qing Cao, Keli L. Hippen, David H. McKenna, Julie Curtsinger, Philip B. McGlave, John E. Wagner

Institutions: University of Minnesota, Masonic Cancer Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650

Funders: National Marrow Donor Program, Children's Cancer Research Fund, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: G1207260132, G1905428511, G2340660310, G2935575925, G345720138, G3732432414, Mechanisms, Prevention and Treatment of Chronic Graft-vs.-Host Disease, G429813519, G4971857153, G6064819280, SOMATIC CELL PROCESSING, G7760935361, T Cell Costimulatory Pathways: Functions and Interactions, NK cells, their receptors and cancer therapy

OpenAlex ID: W2103020736

FWCI: 5.7

Cites: 5

Cited by: 96

Related to: 10