Work

Characterization of a Novel Respiratory Syncytial Virus-Specific Human Cytotoxic T-Lymphocyte Epitope

Year: 2000

Type: article

Abstract: Respiratory syncytial virus (RSV) infection is a major cause of morbidity in childhood worldwide. The first human RSV-specific cytotoxic T-lymphocyte epitope to be defined is described. This HLA B7-restricted epitope in nucleoprotein (NP) was detectable in four healthy, B7-positive adult subjects using B7-RSV-NP tetrameric complexes to stain CD8(+) T cells.

Source: Journal of Virology

DOI: 10.1128/jvi.74.16.7694-7697.2000

Authors: Philip J. R. Goulder, Franziska Lechner, Paul Klenerman, Kenneth McIntosh, Bruce D. Walker

Institutions: Boston Children's Hospital, Massachusetts General Hospital, John Radcliffe Hospital

Language: English

Topic: Respiratory viral infections research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases