Brucella abortus Strain RB51 Leucine Auxotroph as an Environmentally Safe Vaccine for Plasmid Maintenance and Antigen Overexpression
Year: 2008
Type: article
Abstract: To avoid potentiating the spread of an antibiotic resistance marker, a plasmid expressing a leuB gene and a heterologous antigen, green fluorescent protein (GFP), was shown to complement a leucine auxotroph of cattle vaccine strain Brucella abortus RB51, which protected CD1 mice from virulent B. abortus 2308 and elicited GFP antibodies.
DOI: 10.1128/aem.01511-08
Authors: Parthiban Rajasekaran, Mohamed N. Seleem, Andrea Contreras, Endang Purwantini, Gerhardt G. Schurig, Nammalwar Sriranganathan, Stephen M. Boyle
Language: English
Subfield: Small Animals
Field: Veterinary
Domain: Health Sciences
Open Access status: green
Funder: University of Washington
OpenAlex ID: W2103132552