Work

OR11-005 - Mast cells respond to pathogen signals with IL-1ß

Year: 2013

Type: article

Abstract: Mast cells, key effector cells of allergic and innate immune responses, have recently been reported to be an important source of IL-1ß in patients with autoinflammatory conditions such as cryopyrin-associated-periodic-fever syndromes (CAPS). CAPS patients show IL-1beta-driven systemic inflammation together with non-histamine dependent urticarial rash, which are caused by activating mutations of the inflammasome, a multiprotein oligomer responsible for the initiation of inflammatory responses to pathogens.

Source: Pediatric Rheumatology

DOI: 10.1186/1546-0096-11-s1-a194

Authors: L Kraas, O Schmetzer, K Krause, E Latz, M Maurer

Institutions: Charité – Universitätsmedizin Berlin, University Hospital Bonn

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090