Work

The immune responses to bacterial antigens encountered in vivo at mucosal surfaces

Year: 2000

Type: article

Abstract: Mammals have evolved a sophisticated immune system for handling antigens encountered at their mucosal surfaces. The way in which mucosally delivered antigens are handled influences our ability to design effective mucosal vaccines. Live attenuated derivatives of pathogens are one route towards the development of mucosal vaccines. However, some molecules, described as mucosal immunogens, are inherently immunogenic at mucosal surfaces. Studies on mucosal immunogens may facilitate the identification of common characteristics that contribute to mucosal immunogenicity and aid the development of novel, non-living mucosal vaccines and immunostimulators.

Source: Philosophical Transactions of the Royal Society B Biological Sciences

DOI: 10.1098/rstb.2000.0610

Authors: Gordon Dougan, Marjan Ghaem–Maghami, Derek Pickard, Gad Frankel, Gill Douce, Simon Clare, Sarah Dunstan, Cameron Simmons

Institution: Imperial College London

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2103158449

FWCI: 0.112

Cites: 45

Cited by: 6

Related to: 10