Year: 2012
Type: article
Abstract: Enterovirus 71 is a picornavirus that causes hand, foot and mouth disease but may induce fatal neurological illness in infants and young children. Enterovirus 71 crystallized in a body-centered orthorhombic space group with two particles in general orientations in the crystallographic asymmetric unit. Determination of the particle orientations required that the locked rotation function excluded the twofold symmetry axes from the set of icosahedral symmetry operators. This avoided the occurrence of misleading high rotation-function values produced by the alignment of icosahedral and crystallographic twofold axes. Once the orientations and positions of the particles had been established, the structure was solved by molecular replacement and phase extension.
Authors: Pavel Plevka, Rushika Perera, Jane Cardosa, Richard J. Kuhn, Michael G. Rossmann
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
Awards: G102163711, G107546177, G1286251239, G1313983767, G1505794299, G1664757510, G2101401529, G2287611682, G262962599, G2887060908, G3075337988, Structure and Function of Icosahedral Viruses, Structure and function of icosahedral viruses, G340565428, G426311843, BioCARS: A Synchroton Structural Biology Resource, G498139845, G5106849484, G5387317844, G5534982898, G5607048534, G5910536577, G6848031779, G6918803902, G7368700025, G7583137537, G835026943, G9000072102, G9000218060, G969889393, G993149817
OpenAlex ID: W2103213404