Year: 2007
Type: article
Abstract: It has become increasingly obvious that the notion of a terminally differentiated cell is likely a simplified concept. Epithelial-mesenchymal transition (EMT), during which epithelial cells assume a mesenchymal phenotype, is a key event occurring during normal development and pathological processes. Multiple extracellular stimuli and transcriptional regulators can trigger EMT, but how such distinct signaling pathways orchestrate the complex cellular events that facilitate EMT is not well understood. In this issue of the JCI, Venkov et al. report on their examination of fibroblasts resulting from EMT and describe a novel protein-DNA complex that is essential for transcription of fibroblast-specific protein 1 (FSP1) and sufficient to induce early EMT events (see the related article beginning on page 482). Collectively, their results suggest that this complex is an important regulator of the EMT transcriptome.
DOI: 10.1172/jci31200
Authors: Yingqi Teng, Michael Zeisberg, Raghu Kalluri
Institutions: Beth Israel Deaconess Medical Center, Harvard University
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: amfAR, The Foundation for AIDS Research, Elizabeth Glaser Pediatric AIDS Foundation, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences
Awards: G1284056865, Proteomic Analysis of Eukaryotic Protein Synthesis, G2524322585, G2573455840, G2731348330, ZINC FINGERS IN KIDNEY DEVELOPMENT, G3321193713, G4121972351, G4513176822, Molecular Mechanisms of Renal Fibrosis, Structural Biology of U-box E3 Ubiquitin Ligases, Proteomic Construction of Stress Regulated Networks, Regulation of Angiogenesis by Tumstatin, G5262456957, Gene Entrapment Strategy for Proteomics in Mice, Matrix Microenvironment and Liver Fibrosis, Re-Induction of Developmental Programs during Chronic Renal Injury, G605925689, The Biology and Function of BMP-7 in the Kidney, S100 Proteins: Structural Basis of Functional Properties, G6945084169, SPORE in Breast Cancer, Functional Genomics of Inflammation, Assembly of Type IV Collagen in Health and Disease, Cancer Center Support Grant
OpenAlex ID: W2103270060