Linking Cellular Mechanisms to Behavior: Entorhinal Persistent Spiking and Membrane Potential Oscillations May Underlie Path Integration, Grid Cell Firing, and Episodic Memory
Year: 2008
Type: review
Abstract: The entorhinal cortex plays an important role in spatial memory and episodic memory functions. These functions may result from cellular mechanisms for integration of the afferent input to entorhinal cortex. This article reviews physiological data on persistent spiking and membrane potential oscillations in entorhinal cortex then presents models showing how both these cellular mechanisms could contribute to properties observed during unit recording, including grid cell firing, and how they could underlie behavioural functions including path integration. The interaction of oscillations and persistent firing could contribute to encoding and retrieval of trajectories through space and time as a mechanism relevant to episodic memory.
Source: Neural Plasticity
DOI: 10.1155/2008/658323
Authors: Michael E. Hasselmo, Mark P. Brandon
Institution: Boston University
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,830
Awards: G1173918957, Glutamatergic Dysfunction and Schizophrenia, SLC Center: CELEST: A Center for Learning in Education, Science, and Technology, G2003792905, G2840339985, G2980617945, G3174090830, G3375663373, G3829419485, G423157476, G4293757475, G432454829, G4701607673, Neuromodulation and Cortical Memory Function, Mechanisms of Entorhinal Cortex Function, G5717897671, G5954783337, Functional Circuitry of the Hippocampus, G6291248628, G6396983198, G706182635, A Spiking Model of Hippocampus for Guiding Behavior, G820332971
OpenAlex ID: W2103435921