Ets proteins in biological control and cancer
Year: 2004
Type: review
Abstract: The Ets family consists of a large number of evolutionarily conserved transcription factors, many of which have been implicated in tumor progression. Extensive studies on this family of proteins have focused so far mainly on the biochemical properties and cellular functions of individual factors. Since most of the Ets factors can bind to the core consensus DNA sequence GGAA/T in vitro, it has been a challenge to differentiate redundant from specific functions of various Ets proteins in vivo. Recent findings, however, suggest that such apparent redundancy may in fact be a central component of a network of differentially regulated specific Ets factors, resulting in distinct biological and pathological consequences. The programmed "Ets conversion" appears to play a critical role during tumor progression, especially in control of cellular changes during epithelial-mesenchymal transition and metastasis. Coordination of multiple Ets gene functions also mediates interactions between tumor and stromal cells. As such, these new insights may provide a novel view of the Ets gene family as well as a focal point for studying the complex biological control involved in tumor progression.
Source: Journal of Cellular Biochemistry
DOI: 10.1002/jcb.20012
Authors: Tien Hsu, Maria Trojanowska, Dennis K. Watson
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: The molecular mechanism of vasculopathy and fibrosis in scleroderma, VHL tumor suppressor gene and the initiation of renal cell carcinoma, Control of epithelial morphogenesis in Drosphila ovary, Role of Ets Genes in transformation and Differentiation, Role of an Epithelial Ets Factor in Breast Cancer
OpenAlex ID: W2103555733