Work

Micro RNA s (mi RNA s) in the control of HF development and cycling: the next frontiers in hair research

Year: 2015

Type: review

Abstract: Hair follicle development and its postnatal regeneration are characterized by dramatic changes in its microanatomy and cellular activity, which are controlled by multiple signalling pathways, transcription factors and epigenetic regulators, including microRNAs (miRNAs). miRNAs and their targets form remarkably diverse regulatory networks, playing a key role in the execution of gene expression programmes in the different cell lineages of the hair follicle. This review summarizes the roles of miRNAs in the control of hair follicle development, cycling and hair pigmentation, emphasizes the remaining problems/unanswered questions, and provides future directions in this rapidly growing and exciting area of research.

Source: Experimental Dermatology

DOI: 10.1111/exd.12785

Authors: Thomas Andl, Natalia V. Botchkareva

Institutions: Vanderbilt University, University of Bradford

Language: English

Topic: Hair Growth and Disorders

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, Medical Research Council, National Institute of Arthritis and Musculoskeletal and Skin Diseases