Year: 2013
Type: article
Abstract: Chronic stress impairs cognitive function, namely on tasks that rely on the integrity of cortico-limbic networks. To unravel the functional impact of progressive stress in cortico-limbic networks we measured neural activity and spectral coherences between the ventral hippocampus (vHIP) and the medial prefrontal cortex (mPFC) in rats subjected to short term stress (STS) and chronic unpredictable stress (CUS). CUS exposure consistently disrupted the spectral coherence between both areas for a wide range of frequencies, whereas STS exposure failed to trigger such effect. The chronic stress-induced coherence decrease correlated inversely with the vHIP power spectrum, but not with the mPFC power spectrum, which supports the view that hippocampal dysfunction is the primary event after stress exposure. Importantly, we additionally show that the variations in vHIP-to-mPFC coherence and power spectrum in the vHIP correlated with stress-induced behavioral deficits in a spatial reference memory task. Altogether, these findings result in an innovative readout to measure, and follow, the functional events that underlie the stress-induced reference memory impairments.
Source: Frontiers in Neural Circuits
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Awards: G1578237752, A influência de interacções neurónio-glia na progressão de patologias induzidas pelo stress, Reabilitação Cognitiva Baseada em Interface Cérebro-Máquina, G4291086836, THE INTERPLAY BETWEEN ASTROCYTES AND NEURONS IN THE PROGRESSION OF STRESS-INDUCED COGNITIVE DISORDERS, SISTEMA DE CONTROLO PREDITIVO PARA INTERFACE CÉREBRO-MÁQUINA, G8868700560, G8952488736, The interplay between astrocytes and neurons in the progression of stress-induced cognitive disorders
OpenAlex ID: W2103621658