Work

Insulin-like growth factor binding protein-2 alters the sensitivity of breast cancer cells to chemotherapy

Year: 2010

Type: article

Abstract: Insulin-like growth factor binding protein-2 (IGFBP-2) is often elevated in breast tumours and the presence of IGFBP-2 has been shown to correlate with malignancy. Previously we have shown that IGFBP-2 reduces PTEN abundance [ 1 ] and thus helps to maintain the activity of the phosphoinositide 3-kinase signalling cascade, a key mitogenic and survival pathway.

Source: Breast Cancer Research

DOI: 10.1186/bcr2519

Authors: EJ Foulstone, JM Holly, L Zeng, ZE Winters, CM Perks

Institution: University of Bristol

Language: English

Topic: Growth Hormone and Insulin-like Growth Factors

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,190