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The generation of antibody diversity through somatic hypermutation and class switch recombination

Year: 2004
Type: preprint
Abstract: Characteristics of class switch recombinationIn CSR, the Cµ region is replaced by downstream C␥, C␧, or C␣ segments to generate IgG, IgE, and IgA antibodies, respectively.This process is mediated by an intrachromosomal recombinational event between the switch (S) region of the Cµ region (Sµ) and one of the downstream S regions (Fig. 2).These S regions are located immediately upstream of each of the C regions (except for ␦; Fig. 2A) and contain imperfect G-C-rich pentameric repeats that serve as the donors and recipients for a recombinational process that is region specific but not sequence specific (for review, see Stavnezer 2000; Kenter 2003).
DOI: 10.1101/gad.1161904
Language: English
Open Access status: bronze
Funders: Cancer Research Institute, National Institutes of Health, U.S. Public Health Service, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases
Awards: G1452006332, G1981443085, G237964500, G25398982, Mismatch repair in V region mutation and isotype switching, MECHANISM OF ANTIBODY PROTECTION TO C NEOFORMANS, G355014119, Somatic Mutation of IG Variable Regions, Training Program in Cellular and Molecular Biology and Genetics
OpenAlex ID: W2103735815
Cites: 88
Cited by: 342
Related to: 10