Meta-analysis identifies aMECOMgene as a novel predisposing factor of osteoporotic fracture
Year: 2013
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Osteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de novo replication analysis of an East Asian population. METHODS: Association was tested using a logistic regression analysis. A meta-analysis was performed on the combined results using effect size and standard errors estimated for each study. RESULTS: In a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (rs784288 in the MECOM gene) that showed genome-wide significance (p=3.59×10(-8); OR 1.39). RNA interference revealed that a MECOM knockdown suppresses osteoclastogenesis. CONCLUSIONS: Our findings provide new insights into the genetic architecture underlying OF in East Asians.
Source: Journal of Medical Genetics
Authors: Joo-Yeon Hwang, Seung Hun Lee, Min Jin Go, Beom-Jun Kim, Ikuyo Kou, Shiro Ikegawa, Yan Guo, Hong-Wen Deng, Soumya Raychaudhuri, Young Jin Kim, Ji Hee Oh, Youngdoe Kim, Sanghoon Moon, Dong-Joon Kim, Heejo Koo, My-Jung Cha, Min Hye Lee, Ji Young Yun, Hye-Sook Yoo, Young-Ah Kang, Eun-Hee Cho, Sang-Wook Kim, Ki Won Oh, Moo Il Kang, Ho Young Son, Shin-Yoon Kim, Ghi Su Kim, Bok-Ghee Han, Yoon Shin Cho, Myeong-Chan Cho, Jong-Young Lee, Jung-Min Koh
Institutions: Korea National Institute of Health, Kyungpook National University Hospital, Asan Medical Center, University of Ulsan, Istituto Superiore di Sanità, RIKEN, Xi'an Jiaotong University, Broad Institute, Brigham and Women's Hospital, Harvard University, Kangwon National University, Kyungpook National University, Sungkyunkwan University, Catholic University of Korea, Hallym University, National Institutes of Health
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2103758702