Work

A Comprehensive View of Human Chromosome 1

Year: 1999

Type: preprint

Abstract: Comprehensive representations of human chromosomes combining diverse genomic data sets, localizing expressed sequences, and reflecting physical distance are essential for disease gene identification and sequencing efforts. We have developed a method (CompView) for integrating genomic information derived from available cytogenetic, genetic linkage, radiation hybrid, physical, and transcript-based mapping approaches. CompView generates chromosome representations with substantially higher resolution, coverage, and integration than current maps of the human genome. The CompView process was used to build a representation of human chromosome 1, yielding a map with >13,000 unique elements, an effective resolution of 910 kb, and a marker density of 50 kb. CompView creates comprehensive and fully integrated depictions of a chromosome's clinical, biological, and structural information.

Source: Genome Research

DOI: 10.1101/gr.9.10.978

Authors: Peter S. White, Erik P. Sulman, Christopher J. Porter, Tara C. Matise

Institutions: Children's Hospital of Philadelphia, Johns Hopkins University, Johns Hopkins Medicine, University of Pennsylvania, Rockefeller University

Language: English

Topic: Genomic variations and chromosomal abnormalities

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Human Genome Research Institute

Awards: G3327477081, G4148147405, INTEGRATED MAPS USING RADIATION HYBRIDS, G6064600637