Work

Radioimmunotherapy Is Effective against High-Inoculum Cryptococcus neoformans Infection in Mice and Does Not Select for Radiation-Resistant Cryptococcal Cells

Year: 2009

Type: article

Abstract: We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01334-08

Authors: Ruth A. Bryan, Zewei Jiang, Xianchun Huang, Alfred Morgenstern, Frank Bruchertseifer, Rani Sellers, Arturo Casadevall, Ekaterina Dadachova

Institutions: Joint Research Centre, Albert Einstein College of Medicine

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: G1948673602, G2225302221, G2436179761, Synergy of Host Defense Mechanisms in the Lung, G2737691582, G2773611754, G4559384, G4617214234, G5683267944, G620796728, Protective antibodies for Cryptococcal Infections, G6928497940, Biology of Fungal Melanin, G7479519539, G813456599, Molecular Characterization of C. neoformans Antibodies

OpenAlex ID: W2103913475

FWCI: 1.438

Cites: 9

Cited by: 19

Related to: 10