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Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Direct Bacterial Identification from Positive Blood Culture Pellets

Year: 2010

Type: article

Abstract: An ammonium chloride erythrocyte-lysing procedure was used to prepare a bacterial pellet from positive blood cultures for direct matrix-assisted laser desorption-ionization time of flight (MALDI-TOF) mass spectrometry analysis. Identification was obtained for 78.7% of the pellets tested. Moreover, 99% of the MALDI-TOF identifications were congruent at the species level when considering valid scores. This fast and accurate method is promising.

Source: Journal of Clinical Microbiology

DOI: 10.1128/jcm.01780-09

Authors: Guy Prod'hom, Alain Bizzini, Christian Durussel, Jacques Bille, Gilbert Greub

Institution: University of Lausanne

Language: English

Topic: Bacterial Identification and Susceptibility Testing

Subfield: Microbiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2104038839

FWCI: 20.74

Cites: 7

Cited by: 270

Related to: 9