No Association of Type 2 Diabetes Risk Variants and Prostate Cancer Risk: the Multiethnic Cohort and PAGE
Year: 2011
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Epidemiologic studies have found evidence of an inverse association between diabetes status and prostate cancer risk. We explored the hypothesis that common genetic variation may explain, in part, the inverse association between diabetes and prostate cancer. METHODS: We tested 17 diabetes risk variants for association with prostate cancer risk in a prostate cancer case-control study of 2,746 cases and 3,317 controls from five racial/ethnic groups in the Multiethnic Cohort (MEC) study. RESULTS: After adjustment for multiple testing, none of the alleles were statistically significantly associated with prostate cancer risk. Aggregate scores that sum the risk alleles were also not significantly associated with risk. CONCLUSIONS: We did not find evidence of association of this set of diabetes risk alleles with prostate cancer. IMPACT: Resequencing and fine-mapping of the loci for diabetes and prostate cancer that were identified by genome-wide association studies are necessary to understand any genetic contribution for the inverse association between these common diseases.
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Awards: Epidemiology of putative genuine genetic variant: The Women's Health Intiative, Epidemiology of Putative Causal Variants in the Multiethnic Cohort, Multiethnic Cohort Study of Diet and Cancer, NHGRI EpiGenVar Coordinating Center, Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3, G6918065631, Genetic Epidemiology of Causal Variants Across the Life Course, Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study, A Genome-wide Association Study of Prostate Cancer in African Americans, Epidemiologic Architecture for Genes Linked to Environment (EAGLE), University of Hawaii Cancer Center CCSG
OpenAlex ID: W2104041067