Progress in Defining CD4 Helper Cell Responses in Chronic Viral Infections
Year: 2003
Type: article
Abstract: Infection with the AIDS virus has led to an expanding global health crisis, with over 45 million persons currently living with HIV infection. Ineffective immune control and resultant disease progression is a hallmark of this infection, despite the induction of vigorous virus-specific CD8 T cell responses in most infected persons. Although the features of protective immunity in HIV infection remain to be defined, growing evidence points to a critical role for virus-specific CD4 cells. This is consistent with observations in murine models that maintenance of effective antiviral CTL responses in chronic viral infections is critically dependent on virusspecific T helper cells (1–8). A potentially simple explanation for the lack of effective immune control in chronic HIV infection is that HIV selectively infects activated CD4 cells and thereby destroys the
DOI: 10.1084/jem.20031947
Authors: Cheryl L. Day, Bruce D. Walker
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2104172635