Work

Small molecule antagonists of cell-surface heparan sulfate and heparin–protein interactions

Year: 2015

Type: article

Abstract: A series of rationally designed surfen analogs were synthesized and utilized as antagonists of glycosaminoglycan–protein interactions, including the neutralization of the anticoagulant activity of fondaparinux, a synthetic pentasaccharide analog of heparin.

Source: Chemical Science

DOI: 10.1039/c5sc01208b

Authors: Ryan J. Weiss, Philip L. S. M. Gordts, Dzung Le, Ding Xu, Jeffrey D. Esko, Yitzhak Tor

Institutions: University of California System, University of California San Diego, University at Buffalo, State University of New York

Language: English

Topic: Proteoglycans and glycosaminoglycans research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, University of California, San Diego, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences