Work

The Role of Interleukin 17 in Tumour Proliferation, Angiogenesis, and Metastasis

Year: 2014

Type: review

Abstract: With 7.6 million deaths globally, cancer according to the World Health Organisation is still one of the leading causes of death worldwide. Interleukin 17 (IL-17) is a cytokine produced by Th17 cells, a T helper cell subset developed from an activated CD4+ T-cell. Whilst the importance of IL-17 in human autoimmune disease, inflammation, and pathogen defence reactions has already been established, its potential role in cancer progression still needs to be updated. Interestingly studies have demonstrated that IL-17 plays an intricate role in the pathophysiology of cancer, from tumorigenesis, proliferation, angiogenesis, and metastasis, to adapting the tumour in its ability to confer upon itself both immune, and chemotherapy resistance. This review will look into IL-17 and summarise the current information and data on its role in the pathophysiology of cancer as well as its potential application in the overall management of the disease.

Source: Mediators of Inflammation

DOI: 10.1155/2014/623759

Authors: Bob Yang, Heechan Kang, Anthony Fung, Hailin Zhao, Tianlong Wang, Daqing Ma

Institutions: Capital Medical University, Xuan Wu Hospital of the Capital Medical University, Chelsea and Westminster Hospital, Imperial College London

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,040