Work

Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction

Year: 2003

Type: preprint

Abstract: How do very diverse signaling pathways induce neural differentiation in Xenopus? Anti-BMP (Chordin), FGF8, and IGF2 signals are integrated in the embryo via the regulation of Smad1 phosphorylation. Neural induction results from the combined inhibition of BMP receptor serine/threonine kinases and activation of receptor tyrosine kinases that signal through MAPK and phosphorylate Smad1 in the linker region, further inhibiting Smad1 transcriptional activity. This hard-wired molecular mechanism at the level of the Smad1 transcription factor may help explain the opposing activities of IGF, FGF, and BMP signals not only in neural induction, but also in other aspects of vertebrate development.

Source: Genes & Development

DOI: 10.1101/gad.1153603

Authors: Edgar M. Pera, Atsushi Ikeda, Edward Eivers, Eddy M. De Robertis

Institutions: Howard Hughes Medical Institute, University of California, Los Angeles

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Cell-cell communication in Xenopus development, HOMEOBOX GENES AND THEIR TARGETS IN XENOPUS DEVELOPMENT, G7635776776