Work

A Family of Hierarchically Self‐Assembling Linear‐Dendritic Hybrid Polymers for Highly Efficient Targeted Gene Delivery

Year: 2005

Type: article

Abstract: Modular materials composed of concentric functional “shells” with independently tuneable properties are prepared from the self-assembly of DNA and linear-dendritic hybrid polymers (see scheme; PAMAM=poly(amidoamine), PEG=poly(ethylene glycol)). These ligand-targeted systems demonstrate serum stability, low toxicity, and transfection efficiencies that exceed those of the most efficient commercially available polymer poly(ethylenimine).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200502152

Authors: Kris C. Wood, Steven R. Little, Robert Langer, Paula T. Hammond

Institution: Massachusetts Institute of Technology

Language: English

Topic: Dendrimers and Hyperbranched Polymers

Subfield: Polymers and Plastics

Field: Materials Science

Domain: Physical Sciences

Open Access status: bronze