Year: 2014
Type: article
Abstract: Introduction: Protein-based biomaterials can be combined with stem cells to develop therapies that aid in the regeneration of injured spinal cords. These approaches use various protein scaffolds to support the survival and differentiation of implanted stem cell-derived populations into functional neurons and glial cells with the aim of overcoming the inhibitory scarring that restricts cell regrowth after spinal cord injury. The following review evaluates two key protein-based biomaterials–fibrin and collagen–in combination with both pluripotent and multipotent stem cells as strategies for spinal cord injury repair. Recent studies on the protein network of decellularised extracellular matrix are also highlighted as an exciting area for future work. Conclusion: The combination of protein-based biomaterials with stem cells shows significant promise as a strategy for spinal cord injury repair.
Authors: Amy Montgomery, Andrew Agbay, JM Edgar, Nicole Gabers, José Carlos Gómez Sánchez, NK Mohtaram, Craig King, A Mitchell, Azra Rajwani, David Rattray, Megan Robinson, A Shapka, Lin Sun, Alixandra Wong, Stephanie M. Willerth
Language: English
Topic: Spinal Cord Injury Research
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2104460427