Work

The origin of fibroblasts and mechanism of cardiac fibrosis

Year: 2010

Type: review

Abstract: Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that the cardiac fibroblast is a highly heterogenic cell population, and that such heterogeneity is caused by the distinct origins of fibroblasts in the heart. Cardiac fibroblasts can derive either from resident fibroblasts, from endothelial cells via an endothelial-mesenchynmal transition or from bone marrow-derived circulating progenitor cells, monocytes and fibrocytes. Here, we review the function and origin of fibroblasts in cardiac fibrosis.NB. The information given is correct.

Source: Journal of Cellular Physiology

DOI: 10.1002/jcp.22322

Authors: Guido Krenning, Elisabeth M. Zeisberg, Raghu Kalluri

Institutions: Beth Israel Deaconess Medical Center, Harvard University, Harvard–MIT Division of Health Sciences and Technology

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, American Heart Association, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases