Year: 1999
Type: dissertation
Abstract: In its long nucleotide-chains, the DNA double helix contains the genetic information\nfor ten thousands of proteins. The DNA molecule, however, is subject to\nconstant change. In order to l11ailltaill its integrity, several luechallisms that\ncope with DNA damage, inflicted byvarious naturally occurring and man-made\nagents, have evolved. Individuals with the rare genetic disease xeroderma\npigmentosum demonstrate the importance of DNA repair systems. These patients\ncarry a defect in proteins that are involved in the removal ofUV-induced\ndamage from the DNA, which results in sun-sensitivity and the frequent occurrence\nof skin cancers, Hence, studies on DNA repair and human repah' disorders\nsuch as xeroderma pigmentosum
Author: Anneke M. Sijbers
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2104483781