Work

Dissolution profile evaluation of solid pharmaceutical forms containing chloramphenicol marketed in Brazil

Year: 2007

Type: article

Abstract: The dissolution profile for solid pharmaceutical forms containing chloramphenicol 250 mg available in Brazil was determined using a method from the American Pharmacopoeia (United States Pharmacopoeia, 2004) and then compared. Two different methods of dissolution profile comparison were used: ANOVA, and an independent model. Differences between the formulations were reflected in the dissolution profiles. The presence of metastable polymorphs or amorphous forms of chloramphenicol palmitate might be responsible for variations in the concentration of the drug observed within formulations.

Source: Brazilian Archives of Biology and Technology

DOI: 10.1590/s1516-89132007000100007

Authors: Humberto Gomes Ferraz, Leticia Norma Carpentieri, Sayuri Pereira Watanabe

Institutions: Universidade de São Paulo, Universidade de Brasília

Language: English

Topic: Drug Solubulity and Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2104593902

FWCI: 0.24

Cites: 34

Cited by: 17

Related to: 10