Work

Novel Human Adenovirus Strain, Bangladesh

Year: 2012

Type: article

Abstract: We report a novel human adenovirus D (HAdV-65) isolated from feces of 4 children in Bangladesh who had acute gastroenteritis.Corresponding genes of HAdV-65 were related to a hexon gene of HAdV-10, penton base genes of HAdV-37 and HAdV-58, and a fi ber gene of HAdV-9.This novel virus may be a serious threat to public health.H uman adenoviruses (HAdVs) are common pathogens that cause several diseases, such as pneumonia, acute gastroenteritis, and epidemic keratoconjunctivitis (1).HAdV infection is also associated with a serious adenovirus syndrome in immunocompromised patients after stem cell transplantation (2).Acute gastroenteritis causes illness and death in humans worldwide.Illness is associated with infection of enteric viruses, including rotavirus, astrovirus, norovirus, sapovirus, and adenovirus.HAdVs are divided into 7 species (HAdV-A-G) on the basis of DNA genome homology.Most acute gastroenteritis related to HAdVs is caused by HAdV-F species 4).Recently, we detected HAdV-D in feces of children with diarrhea in Bangladesh (5).Other HAdV-D strains have also been associated with diarrhea in Kenya and Brazil (6,7).We report a novel HAdV-D (HAdV-65) strain detected in feces of 4 children with acute gastroenteritis during October 2004-March 2005 in Bangladesh (5) and results of hexon, penton base, and fi ber gene sequence analyses.We also report the full genome sequence of this virus, whose corresponding genes are closely related to the hexon gene of HAdV-10, penton base genes of HAdV-37 and HAdV-58, and the fi ber gene of HAdV-9.

Source: Emerging infectious diseases

DOI: 10.3201/eid1805.111584