Work

Ultrabright and Bioorthogonal Labeling of Cellular Targets Using Semiconducting Polymer Dots and Click Chemistry

Year: 2010

Type: article

Abstract: All aboard! A facile conjugation method allows covalent linking of functional molecules to semiconducting polymer dots for bioorthogonal labeling of cellular targets. Targeting of the polymer dots to newly synthesized proteins and glycoproteins in mammalian cells by click chemistry is highly efficient and specific.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201004260

Authors: Changfeng Wu, Yuhui Jin, Thomas Schneider, Daniel R. Burnham, Polina B. Smith, Daniel T. Chiu

Institution: University of Washington

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institute on Aging, National Cancer Institute, National Institute of Neurological Disorders and Stroke