Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals
Year: 2009
Type: article
Abstract: OBJECTIVE: To estimate whether HIV-infected pregnant women were at an increased risk of hepatotoxicity when taking nevirapine (NVP)-containing regimens compared with HIV-infected pregnant women taking antiretroviral therapy (ART) not containing NVP. METHODS: This analysis included HIV-infected pregnant women on ART from two multicenter, prospective cohorts: the Women and Infants Transmission Study and the International Maternal Pediatric Adolescent AIDS Clinical Trials protocol P1025. Multivariate Cox proportional hazards regression models were used to investigate the association between NVP use and hepatotoxicity. NVP use was dichotomized as use or no use and further categorized according to ART exposure history. We investigated two outcomes: any liver enzyme elevation (LEE) (grade 1-4) and severe LEE (grade 3-4). RESULTS: A total of 1229 women with ART use during pregnancy were studied, 218 (17.7%) of whom received NVP. Among the women receiving NVP, 137 (62.8%) were NVP naive. Twenty-nine women (13.3%) who received NVP developed any LEE and one (0.5%) developed severe LEE. Of the 1011 women on non-NVP regimens, 145 (14.3%) developed any LEE and 14 (1.4%) developed severe LEE. There were no maternal deaths. In univariate models, LEE was not significantly associated with CD4 cell count above 250 cells/mul or NVP use. In adjusted multivariate models, no significant increased risk of LEE (any or severe) in women taking NVP was detected as compared to those taking other ART regardless of prior exposure history. CONCLUSION: We did not observe an increased risk of hepatotoxicity among HIV-infected pregnant women on NVP versus other ART, including women who were ART naive.
Source: AIDS
Authors: David W Ouyang, Susan B Brogly, Ming Lu, David E Shapiro, Ronald C Hershow, Audrey L French, Robert M Leighty, Bruce Thompson, Ruth E Tuomala
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Women and Infants Transmission Study (WITS), G1307617006, WOMEN AND INFANTS TRANSMISSION STUDY, G2231598887, Statistical and Data Management Center-Pediatric,Adolescent, and Maternal CTG, Women and Infants Transmission Study (WITS IV), G2697936944, G3044210939, G3126028604, G3217561614, SIGNALING &METABOLIC ROLES OF GLUCOSE IN SPERM, Women and Infants Transmission Study IV, International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Group, Women and Infants Transmission Study IV - Chicago, General Clinical Research Center, G760152555, Women and Infant Transmission Study, GENERAL CLINICAL RESEARCH CENTER, STATISTICAL &CLINICAL COORDINATING CENTER (SACCC)
OpenAlex ID: W2104725842