Work

TP53 and MTOR crosstalk to regulate cellular senescence

Year: 2010

Type: editorial

Abstract: The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversible senescence, thereby adding yet another level of complexity to the signaling network that emanate from TP53.

Source: Aging

DOI: 10.18632/aging.100202

Authors: Lorenzo Galluzzi, Oliver Kepp, Guido Kroemer

Institutions: Université Paris-Sud, Inserm, Institut Gustave Roussy, Centre de Recherche des Cordeliers, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Université Paris Descartes

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Association pour la Recherche sur le Cancer, European Commission, Agence Nationale de la Recherche, AXA Research Fund, Fondation pour la Recherche Médicale, Institut National Du Cancer

OpenAlex ID: W2104919578

Cites: 13

Cited by: 81

Related to: 10