Meta- and Pooled Analysis of GSTP1 Polymorphism and Lung Cancer: A HuGE-GSEC Review
Year: 2009
Type: article
Study designs: Systematic Review, Meta-Analysis
Abstract: Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A --> 313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio = 1.11, 95% confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the Ile/Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwn417
Authors: M. L. Cote, W. Chen, D. W. Smith, S. Benhamou, C. Bouchardy, D. Butkiewicz, K. M. Fong, M. Gene, A. Hirvonen, C. Kiyohara, J. E. Larsen, P. Lin, O. Raaschou-Nielsen, A. C. Povey, E. Reszka, A. Risch, J. Schneider, A. G. Schwartz, M. Sorensen, J. To-Figueras, S. Tokudome, Y. Pu, P. Yang, A. S. Wenzlaff, H. Wikman, E. Taioli
Institutions: Wayne State University, The Barbara Ann Karmanos Cancer Institute, Inserm, Institut Gustave Roussy, The Maria Sklodowska-Curie National Research Institute of Oncology, Prince Charles Hospital, Prince Charles Hospital, Universitat de Barcelona, Finnish Institute of Occupational Health, Kyushu University, The University of Texas Southwestern Medical Center, Chung Shan Medical University, Danish Cancer Society, University of Manchester, Nofer Institute of Occupational Medicine, German Cancer Research Center, Justus-Liebig-Universität Gießen, Nagoya City University, Southeast University, University Medical Center Hamburg-Eppendorf, University of Pittsburgh
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: National Cancer Institute
Award: SPORE in Lung Cancer
OpenAlex ID: W2104967987