Work

Similarities of an Autoantigen in Aneurysmal Disease of the Human Abdominal-Aorta to a 36-kDa Microfibril-Associated Bovine Aortic Glycoprotein

Year: 1995

Type: article

Abstract: Immunoglobulin G (IgG) from human aneurysmal aorta was used to partially purify an aortic protein with an apparent MW approximately 80 kDa. Amino acid sequencing of a tryptic digest revealed two sequences with homology to mouse tenascin-X. The autoimmune IgG was then shown to react with purified human tenascin, and a rabbit polyclonal anti-human tenascin antibody was found to react with the purified autoantigen. These observations suggest that the autoantigen of abdominal aortic aneurysm disease may be homologous to a calcium-binding member of the tenascin superfamily that has been identified by others in pig and cow.

Source: Biochemical and Biophysical Research Communications

DOI: 10.1006/bbrc.1995.2095

Author: M.D. Tilson

Institutions: St. Luke's-Roosevelt Hospital Center, Columbia University

Language: English

Topic: Aortic aneurysm repair treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,110