Work

Synthesis of conformationally locked carbocyclic nucleoside phosphonates to probe the active site of HIV-1 RT

Year: 2008

Type: conference-paper

Abstract: The conformationally locked carbocyclic nucleoside phosphonates 2 and 2' and key intermediates for the synthesis of 3 and 3' were prepared from a chiral cyclopentene derivative and epicholorohydrine, respectively. The structure of the nucleoside precursor 6 was confirmed by X-ray crystallography. These carbocyclic nucleoside phosphonates were designed to probe their binding interactions at the active site of HIV-1-RT.

Source: Nucleic Acids Symposium Series

DOI: 10.1093/nass/nrn315

Authors: H. Saneyoshi, B. C. Vu, S. H. Hughes, P. L. Boyer, S. G. Sarafianos, V. E. Marquez