Clinical and Virologic Manifestations of Primary Epstein-Barr Virus (EBV) Infection in Kenyan Infants Born to HIV-Infected Women
Year: 2013
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Human immunodeficiency virus (HIV) infection is a risk factor for Epstein-Barr virus (EBV)-associated lymphomas. Characterizing primary infection may elucidate risk factors for malignancy. METHODS: To describe clinical and virologic manifestations of primary EBV infection among infants born to HIV-infected women, specimens were utilized from a cohort study conducted in Nairobi, Kenya. HIV and EBV viral loads were measured serially in plasma. EBV serology was performed on EBV DNA-negative infants. Monthly clinical examinations were performed by pediatricians. RESULTS: The probability of EBV infection by 1 year of age was .78 (95% CI, .67-.88) in HIV-infected and .49 (95% CI, .35-.65) in HIV-uninfected infants (P < .0001). At 2 years, probability of EBV infection was .96 (95% CI, .89-.99) in HIV-infected infants. Peak EBV loads were higher in HIV-infected versus HIV-uninfected infants (median 2.6 vs 2.1 log10 copies/mL; P < .0001). The majority of HIV-infected infants had detectable EBV DNA for >3 months (79%). Primary EBV infection was associated with cough, fever, otitis media, pneumonia, hepatomegaly, splenomegaly, and hospitalization in HIV-infected infants; conjunctivitis and rhinorrhea in HIV-uninfected infants. CONCLUSIONS: EBV infection occurs early in infants born to HIV-infected women. HIV infection was associated with more frequent and higher quantity EBV DNA detection.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Fred Hutchinson Cancer Research Center, University of Washington, National Institutes of Health, Center for AIDS Research, University of Washington, National Cancer Institute, National Institute of Allergy and Infectious Diseases, Fogarty International Center, Office of Research on Women's Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1255415169, Pediatric HIV-1 in Africa: Pathogenesis and Management, G2213881162, G2219438539, AIDS International Training and Research Program, G3985073149, G4160532866, G4266498966, G6625095162, Vertical CMV transmission in the setting of maternal HIV-1 infection in Kenya, G7791962275, G9000186388, University of Washington/Fred Hutch Center for AIDS Research, Cancer Center Support Grant, Pediatric HIV reservoir determinants and consequences
OpenAlex ID: W2105505081