Work

Interaction Between Eye Pigment Genes and Tau-Induced Neurodegeneration inDrosophila melanogaster

Year: 2010

Type: article

Abstract: Null mutations in the genes white and brown, but not scarlet, enhance a rough eye phenotype in a Drosophila melanogaster model of tauopathy; however, adding rosy mutations suppresses these effects. Interaction with nucleotide-derived pigments or increased lysosomal dysregulation are potential mechanisms. Finally, tau toxicity correlates with increased GSK-3β activity, but not with tau phosphorylation at Ser202/Thr205.

Source: Genetics

DOI: 10.1534/genetics.110.119545

Authors: Surendra S Ambegaokar, George R Jackson

Institutions: University of California, Los Angeles, The University of Texas Medical Branch at Galveston

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Health Assistance Foundation, National Institute on Aging, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke