Suppressor Scanning at Positions 177 and 236 in the Escherichia coli Lactose/H + Cotransporter and Stereotypical Effects of Acidic Substituents That Suggest a Favored Orientation of Transmembrane Segments Relative to the Lipid Bilayer
Year: 1998
Type: article
Abstract: Acidic substituents for Ala-177 (helix 6) or Tyr-236 (helix 7) in LacY cause effects on sugar recognition and cosubstrate coupling that are stereotypical of neutral substituents. Thus, helices 6 and 7 are probably oriented to produce little side-chain contact with the low dielectric lipid bilayer at positions 177 and 236.
Source: Journal of Bacteriology
Authors: Steven C. King, Suzhen Li
Institution: The University of Texas Medical Branch at Galveston
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2105657428