Work

Synthesis and Sensing of Bisphosphonophosphate Alkyl Monoesters: A Novel Class of Compounds for the Study of Nucleoside 5′-Triphosphate Chemistry

Year: 2011

Type: article

Abstract: A series of novel β,γ-methylene-, monofluoromethylene-, and difluoromethylene-bisphosphonophosphate alkyl monoesters was synthesized. The compounds were conveniently detected during preparative HPLC using post-column derivatization with a phosphate-specific chemosensor.

Source: Phosphorus, sulfur, and silicon and the related elements

DOI: 10.1080/10426507.2010.526675

Authors: Brian T. Chamberlain, Jorge Osuna, Boris A. Kashemirov, Charles E. McKenna

Institution: University of Southern California

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Cancer Institute

Award: DNA Polymerase Fidelity Mechanisms: Theory and Experiment