Work

Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia

Year: 2011

Type: preprint

Abstract: Long-term memory and plasticity, including long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse, depend on the activation of transcription factors that regulate genes necessary for synaptic plasticity. In the present study we found that treatment with 5-HT and behavioral training produce biphasic changes in the expression of CREB2, a transcriptional repressor. An immediate increase in CREB2 protein was followed by a subsequent decrease. The effects of these treatments persist for at least 24 h and are observed in isolated sensory neurons. This study suggests that the dynamics of CREB2 expression could contribute to the consolidation of memory.

Source: Learning & Memory

DOI: 10.1101/lm.2112111

Authors: Rong-Yu Liu, Shreyansh Shah, Leonard J. Cleary, John H. Byrne

Institutions: The University of Texas at Austin, The University of Texas Health Science Center at Houston

Language: English

Topic: Memory and Neural Mechanisms

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke