Work

Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function

Year: 2010

Type: review

Abstract: G protein-coupled receptors (GPCRs) are versatile signaling molecules that mediate the majority of physiological responses to hormones and neurotransmitters. Recent high-resolution structural insights into GPCR structure and dynamics are beginning to shed light on the molecular basis of this versatility. We use energy landscapes to conceptualize the link between structure and function.

Source: Physiology

DOI: 10.1152/physiol.00002.2010

Authors: Xavier Deupi, Brian K. Kobilka

Institutions: Universitat Autònoma de Barcelona, Stanford Medicine, Stanford University

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of Neurological Disorders and Stroke

Awards: G170481060, G Protein Coupled Receptor Structure, Dynamics and Signaling, Beta2 Adrenoceptor Structure and Mechanism of Activation