Work

Fragment-Based Screening of the Bromodomain of ATAD2

Year: 2014

Type: article

Abstract: Cellular and genetic evidence suggest that inhibition of ATAD2 could be a useful strategy to treat several types of cancer. To discover small-molecule inhibitors of the bromodomain of ATAD2, we used a fragment-based approach. Fragment hits were identified using NMR spectroscopy, and ATAD2 was crystallized with three of the hits identified in the fragment screen.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/jm501035j

Authors: Mary J. Harner, Brian A. Chauder, Jason Phan, Stephen W. Fesik

Institution: Vanderbilt University

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500