Circulating Oxidized Low Density Lipoprotein and Non-High Density Lipoprotein Cholesterol Concentrations in Metabolic Syndrome Egyptian Women Before and After Specific Nutritional Therapy
Year: 2012
Type: article
Study design: Clinical Trial
Abstract: Aim: To investigate the relation between the metabolic syndrome (MetS), and oxidized low density lipoprotein (ox-LDL) and non-high density lipoprotein cholesterol (non-HDL-C), and to evaluate a dietary therapy composed of a balanced hypocaloric regimen plus a supplement prepared from whole wheat and tigernut flour (Cyperus Esculentus).Material and Methods: Forty two obese Egyptian female volunteers (their mean age was 47.76± 0.90) were given a low caloric balanced diet (900-1000 kcal) for 4 weeks, and then the supplement was used to replace Baladi bread during the next four weeks.The metabolic syndrome was diagnosed according to the International Diabetes Federation criteria.Results: The prevalence rate of MetS was found to be 76.2%.The metabolic syndrome was significantly associated with higher levels of total cholesterol (T.cholesterol), LDL-C, ox-LDL and non HDL-C.Significant and sustained reduction in the levels of fasting blood glucose and HbA1c, normalization of lipid profile, and decrease in the levels of ox-LDL were observed after the end of the two periods of the dietary therapy.Conclusion: Metabolic syndrome is associated with higher levels of circulating ox-LDL and non-HDLC.The use of the dietary therapy composed of balanced hypocaloric regimen plus a supplement rich in antioxidants and anti-inflammatory components, reduced obesity and the risky biochemical markers of the MetS. OPEN ACCESS
Authors: Moaty, Maha I. A., El Shebini, Salwa M., Mohamed, Magda S., El-Arabi, Nihad H. A., Tapozada, Salwa T., Hanna, Laila M.
Institution: National Research Centre
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4239391018