Work

Coxsackievirus B3 adapted to growth in RD cells binds to decay-accelerating factor (CD55)

Year: 1995

Type: article

Abstract: A coxsackievirus B3 (CB3) isolate adapted to growth in RD cells shows an alteration in cell tropism as a result of its capacity to bind a 70-kDa cell surface molecule expressed on these cells. We now show that this molecule is the complement regulatory protein, decay-accelerating factor (DAF) (CD55). Anti-DAF antibodies prevented CB3 attachment to the cell surface. Radiolabeled CB3 adapted to growth in RD cells bound to CHO cells transfected with human DAF, whereas CB3 (strain Nancy), the parental strain, did not bind to DAF transfectants. These results indicate that growth of CB3 in RD cells selected for a virus strain that uses DAF for cell surface attachment.

Source: Journal of Virology

DOI: 10.1128/jvi.69.3.1903-1906.1995

Authors: J M Bergelson, J G Mohanty, R L Crowell, N F St John, D M Lublin, R W Finberg

Institution: Dana-Farber Cancer Institute

Language: English

Topic: Viral Infections and Immunology Research

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases