Work

Harboring of Particulate Allergens within Secretory Compartments by Mast Cells following IgE/FcεRI-Lipid Raft-Mediated Phagocytosis

Year: 2006

Type: article

Abstract: Although much is known regarding the exocytic responses of mast cells following allergen/IgE-mediated activation, little is currently known of the fate of the activating allergens, many of which are particles. We have found that IgE-bound particulate allergens were phagocytosed by activated mast cells in a lipid raft-dependent manner. The nascent allergen-containing phagosomes were found to transform into granule compartments by acquiring VAMP7 and serotonin and exhibited the capacity to empty their contents upon mast cell activation. When allergen-harboring mast cells were stimulated, the intracellular allergens were expelled intact and shown to activate adjacent mast cells. This capacity of mast cells to phagocytose and retain whole and antigenically intact allergens could potentially contribute to the course of inflammatory diseases such as asthma.

Source: The Journal of Immunology

DOI: 10.4049/jimmunol.177.9.5791

Authors: Jeoung-Sook Shin, Christopher P Shelburne, Cong Jin, E Ann LeFurgey, Soman N Abraham

Institutions: Duke Medical Center, Duke University

Language: English

Topic: Mast cells and histamine

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases